CDBIM (Center for Disease Biology and Integrative Medicine), Graduage School of Medicine, The University of Tokyo

Nanotechnology, attracting tremendous attention as a leading scientific field in the 21st century, attempts to process and assemble materials with precision at the atomic/molecular level to produce units with sophisticated functions. Nanomedicines produced by nanotechnology hold the key to realizing the futuristic medical system that can serve the needed function at the right time and the right place with minimal invasiveness. Furthermore, nanomedicines are expected to become an important interface between basic biomedical science and clinical medicine by facilitating the translation of basic achievements into clinical applications. We actively collaborate and have an interchange of graduate students with Graduate Schools of Engineering & Medicine at The University of Tokyo and The University of Tokyo Hospital. Our division contributes to The Research Cluster for Frontier Medicine Development at The University of Tokyo Hospital and The Center for NanoBio Integration (CNBI) at The University of Tokyo. Also, our division plays a major role in Global COE program "Medical System Innovation through Multidisciplinary Integration" as a new educational program, which is to be established to train students who will lead the interdisciplinary filed of medicine, engineering and pharmaceutical science, including the standpoint of practical application and industrialization.

<Original papers>

1. S. Uchida, K. Itaka, H. Uchida, K. Hayakawa, T. Ogata, T. Ishii, S. Fukushima, K. Osada, K. Kataoka, In vivo messenger RNA introduction into the central nervous system using polyplex nanomicelle. PLoS One 8 (2) e56220 (2013)
2. M. Naito, T. Ishii, A. Matsumoto, K. Miyata, Y. Miyahara, K. Kataoka, A phenylboronate-functionalized polyion complex micelle for ATPTriggered release of siRNA. Angew. Chem. Int. Ed. 51 (43) 10751-10755 (2012)
3. R. J. Christie, Y. Matsumoto, K. Miyata, T. Nomoto, S. Fukushima, K. Osada, J. Halnaut, F. Pittella, H. -J. Kim, N. Nishiyama, K. Kataoka, Targeted polymeric micelles for siRNA treatment of experimental cancer by intravenous injection. ACS Nano 6 (6) 5174-5189 (2012)
4. S. Uchida, K. Itaka, Q. Chen, K. Osada, T. Ishii, MA. Shibata, M. Harada-Shiba, K. Kataoka, PEGylated polyplex with optimized PEG shielding enhances gene introduction in lungs by minimizing inflammatory responses. Mol. Ther. 20 (6) 1196-1203 (2012)
5. H. Cabral, Y. Matsumoto, K. Mizuno, Q. Chen, M. Murakami, M. Kimura, Y. Terada, M. R. Kano, K. Miyazono, M. Uesaka, N. Nishiyama, K. Kataoka, Accumulation of sub-100nm polymeric micelles in poorly permeable tumours depends on size. Nat. Nanotech. 6 (12) 815-823 (2011)
6. H. Uchida, K. Miyata, M. Oba, T. Ishii, T. Suma, K. Itaka, N. Nishiyama, K. Kataoka, Odd-even effect of repeating aminoethylene units in the side chain of N-substituted polyaspartamides on gene transfection profiles. J. Am. Chem. Soc. 133 (39) 15524-15532 (2011)

<Review papers>

1. K. Miyata, N. Nishiyama, K. Kataoka, Rational design of smart supramolecular assemblies for gene delivery: Chemical challenges in the creation of artificial viruses. Chem. Soc. Rev. 41 (7) 2562-2574 (2012)
2. K. Itaka, K. Kataoka, Progress and prospects of polyplex nanomicelles for plasmid DNA delivery. Curr. Gene Ther. 11 (6) 457-465 (2011)
3. H. Cabral, N. Nishiyama, K. Kataoka, Supramolecular nanodevices: From design validation to theranostic nanomedicine. Acc. Chem. Res. 44 (10) 999-1008 (2011)