MicroEnvironmental and Metabolic Health Sciences

Professor: Makoto Murakami
Associate Prof.: Seiichiroh Ohsako
Assistant Prof.: Yoshitaka Taketomi

1. Research
"Quality of Lipids (QOL)" for "Quality of Life (QOL)"
Lipids serve as the largest energy source, cell membrane components, and bioactive mediators. Lipids are major environmental substances supplied as nutrients and spatiotemporally regulate a variety of biological responses in response to given microenvironmental cues within tissues. Our research focuses on the regulation of biological networks driven by lipids and their metabolites. By taking advantages of an array of gene-manipulated mice for lipid-metabolizing enzymes and receptors, we aim to clarify novel lipid-orchestrated mechanisms underlying various diseases such as metabolic and immune disorders. Knowledges obtained from these approaches will be translated to humans toward discovery of new biomarkers or druggable targets.
2. Publications
  1. Irie A, Yamamoto K, Miki Y, Murakami M. Phosphatidylethanolamine dynamics are required for osteoclast fusion. Sci. Rep. 7, 46715, 2017
  2. Hirabayashi T, Anjo T, Kaneko A, Senoo Y, Shibata A, Takama H, Yokoyama K, Nishito Y, Ono T, Taya C, Muramatsu K, Fukami K, Muñoz-Garcia A, Brash AR, Ikeda K, Arita M, Akiyama A, Murakami M. PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis. Nat. Commun. 8, 14609, 2017
  3. Murakami M, Yamamoto K, Miki Y, Murase R, Sato H, Taketomi Y. The roles of the secreted phospholipase A2 (sPLA2) gene family in immunology. Adv. Immunol. 132, 91-134, 2016
  4. Yamamoto K, Miki Y, Sato H, Nishito Y, Gelb MH, Taketomi Y, Murakami M. Expression and function of group IIE phospholipase A2 in mouse skin. J. Biol. Chem. 291, 15602-15613, 2016
  5. Miki Y, Kidoguchi Y, Sato M, Taketomi Y, Taya C, Muramatsu K, Gelb MH, Yamamoto K, Murakami M. Dual roles of group IID phospholipase A2 in inflammation and cancer. J. Biol. Chem. 291, 15588-15601, 2016
  6. Murase R, Sato H, Yamamoto K, Ushida A, Nishito Y, Ikeda K, Kobayashi T, Yamamoto T, Taketomi Y, Murakami M. Group X secreted phospholipase A2 releases ω-3 polyunsaturated fatty acids, suppresses colitis and promotes sperm fertility. J. Biol. Chem. 291, 6895-6911, 2016
  7. Yamamoto K, Miki Y, Sato M, Taketomi Y, Nishito Y, Taya C, Muramatsu K, Ikeda K, Nakanishi H, Taguchi R, Kambe N, Kabashima K, Lambeau G, Gelb MH, Murakami M. The role of group IIF secreted phospholipase A2 in epidermal homeostasis and hyperplasia. J. Exp. Med. 212, 1901-1919, 2015
  8. Vijay R, Gelb MH, Miki Y, Yamamoto K, Murakami M, Perlman S. Critical role for secreted phospholipase A2 group IID in age-related susceptibility to infection with the severe acute respiratory syndrome coronavirus. J. Exp. Med. 212,1851-1868, 2015
  9. Sato H, Taketomi Y, Ushida A, Isogai Y, Kojima T, Hirabayashi T, Miki Y, Yamamoto K, Nishito Y, Kobayashi T, Ikeda K, Taguchi R, Hara S, Ida S, Miyamoto Y, Watanabe M, Baba H, Miyata K, Oike Y, Gelb MH, Murakami M. The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity. Cell Metab. 20, 119-132, 2014
  10. Taketomi Y, Ueno N, Kojima T, Sato H, Murase R, Yamamoto K, Tanaka S, Sakanaka M, Nakamura M, Nishito Y, Kawana M, Kambe N, Ikeda K, Taguchi R, Nakamizo S, Kabashima K, Gelb MH, Arita M, Yokomizo T, Nakamura M, Watanabe K, Hirai H, Nakamura M, Okayama Y, Ra C, Aritake K, Urade Y, Morimoto K, Sugimoto Y, Shimizu T, Narumiya S, Hara S, Murakami M. Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. Nat. Immunol. 14, 554-563, 2013
  11. Miki Y, Yamamoto K, Taketomi Y, Sato H, Shimo K, Kobayashi T, Ishikawa Y, Ishii T, Nakanishi H, Ikeda K, Taguchi R, Kabashima K, Arita M, Arai H, Lambeau G, Bollinger JM, Hara S, Gelb MH, Murakami M. Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving anti-inflammatory lipid mediators. J. Exp. Med. 210, 1217-1234, 2013
  12. Sato H, Isogai Y, Masuda S, Taketomi Y, Miki Y, Kamei D, Hara S, Kobayashi T, Ishikawa Y, Ishii T, Ikeda K, Taguchi R, Ishimoto Y, Suzuki N, Yokota Y, Hanasaki K, Suzuki-Yamamoto T, Yamamoto K, Murakami M. Physiological roles of group X secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function. J. Biol. Chem. 286, 11616-11631, 2011
  13. Sato H, Taketomi T, Isogai Y, Miki Y, Yamamoto K, Masuda S, Hosono T, Arata S, Ishikawa Y, Ishii T, Kobayashi T, Nakanishi H, Ikeda K, Taguchi R, Hara S, Kudo I, Murakami M. Group III secreted phospholipase A2 regulates epididymal sperm maturation and fertility in mice. J. Clin. Invest. 120, 1400-1414, 2011