Laboratories / Div. of Research Resources & Support

Animal Resources /
Section of Animal Research

Professor: Atsu Aiba
Associate Professor: Kazutaka Nakao

1. Research
Our laboratory focuses on understanding the molecular mechanisms which underlie the synaptic plasticity, activity dependent formation of neuronal circuitry, and learning and memory. We generate knockout mice and inducible knockout mice of signal transduction molecules including the glutamate receptors and Rho family GTPases. We have recently applied proteomics analysis to these mice. We also try to generate murine models for human genetic diseases.
2. Publications
  1. Kassai H, Terashima T, Fukaya M, Nakao K, Sakahara M, Watanabe M, and Aiba A. Rac1 in cortical projection neurons is selectively required for midline crossing of commissural axonal formation. Eur. J. Neurosci., 28, 257-267, (2008).
  2. Ohtani Y, Harada T, Funasaka Y, Nakao K, Takahara C, Abdel-Daim M, Sakai N, Saito N, Nishigori C, and Aiba A. Metabotropic glutamate receptor subtype-1 is essential for in vivo growth of melanoma. Oncogene, 27, 7162-7170, (2008).
  3. Ito K, Kawasaki T, Takashima S, Matsuda I, Aiba A, and Hirata T. Semaphorin 3F confines ventral tangential migration of lateral olfactory tract neurons onto the telencephalon surface. J. Neurosci., 28, 4414-4422, (2008).
  4. Nakao H, Nakao K, Kano M, and Aiba A. Metabotropic glutamate receptor subtype-1 is essential for motor coordination in the adult cerebellum. Neurosci Res, 57, 538-543, (2007).
  5. Kassai H, Aiba A, Nakao K, Nakamura K, Katsuki M, Xiong WH, Yau KW, Imai H, Shichida Y, Satomi Y, Takao T, Okano T, and Fukada Y. Farnesylation of retinal transducin underlies its translocation during light adaptation. Neuron, 47, 529-539, (2005).