東京大学 伊藤研究室

東京大学大学院医学系研究科 疾患生命工学センター 医療材料・機器工学部門

English

Profile


太田 誠一 (Seiichi Ohta)


研究分野

  • 化学工学
  • コロイド化学
  • バイオマテリアル

略歴

2008年3月
東京大学 工学部 化学システム工学科卒業
2010年3月
東京大学 大学院工学系研究科化学システム工学専攻 修士課程修了
2010年4月
東京大学 大学院工学系研究科化学システム工学専攻 日本学術振興会・特別研究員DC1
2013年3月
東京大学 大学院工学系研究科化学システム工学専攻 博士課程修了 博士(工学)
2013年4月
東京大学 大学院医学系研究科 疾患生命工学センター 日本学術振興会・特別研究員PD
2014年3月-2015年9月
Institute of Biomaterials & Biomedical Engineering (IBBME),University of Toronto Postdoctoral Fellow (JSPS Research Fellow PD)
2016年4月
東京大学 大学院医学系研究科 疾患生命工学センター・助教

受賞

  • AsiaNano 2010 Young Researcher Award
  • 第32回日本バイオマテリアル学会大会 若手研究者大会長賞
  • 東京大学大学院 工学系研究科長賞
  • 平成30年度 化学工学会 研究奨励賞(玉置明善記念賞)

研究業績

  1. K. Mitsuhashi, P. Qi, A. Takahashi, S. Ohta, and T. Ito
    "Prevention of postoperative peritoneal adhesions in rats with sidewall defect-bowel abrasions using metal ion-crosslinked N-succinyl chitosan hydrogels"
    React. Funct. Polym. (in press)
  2. P. Qi, Y. G. Zheng, S. Ohta, N. Kokudo, K. Hasegawa, and T. Ito
    "The In situ fabrication of double-layered hydrogels via spray processes to prevent postoperative peritoneal adhesion"
    ACS Biomater. Sci. Eng. (in press)
  3. Y. Amano, S. Ohta, K. L. Sakura, and T. Ito
    "The Pemetrexed-conjugated hyaluronan for the treatment of malignant pleural mesothelioma"
    Eur. J. Pharm. Sci. 138 (2019) 105008.
  4. Y. Oki, K. Kirita, S. Ohta, S. Ohba, I. Horiguchi, Y. Sakai, and T. Ito
    "Switching of cell proliferation/differentiation in thiol-maleimide clickable microcapsules triggered by in situ conjugation of biomimetic peptides"
    Biomacromol. 20 (2019) 2350–2359.
  5. S. Ohta, T. Toda, F. Inagaki, K. Omichi, A. Shimizu, N. Kokudo, K. Hasegawa, and T. Ito
    "The Prevention of Hepatectomy-induced Adhesions by Bilayer Sponge Composed of Ultrapure Alginate"
    J. Surg. Res. 242 (2019) 286–295.
  6. S. Ohta, M. Matsuura, Y. Kawashima, M. Taniguchi, H. Okochi, Y. Asano, S. Sato, and T. Ito
    "Facile fabrication of PEG-coated PLGA microspheres via SPG membrane emulsification for the treatment of scleroderma by ECM degrading enzymes"
    Coll. Surf. B Biointerfaces 179 (2019) 453–461.
  7. D. Glancy, Y. Zhang, J. L. Y. Wu, B. Ouyang, S. Ohta, and W. C. W. Chan
    "Characterizing the protein corona of sub-10 nm nanoparticles"
    J. Control. Release 304 (2019) 102–110.
  8. F. Tanaka, Y. Nakagawa, S. Ohta, and T. Ito
    "Thermoreversible gelation with ion-binding cross-links of variable multiplicity"
    J. Chem. Phys. 150 (2019) 174904.
  9. X. Fu, S. Ohta, M. Kamihira, Y. Sakai,and T. Ito
    "Size-controlled Preparation of Micro-sized Perfluorocarbon Emulsions as Oxygen Carriers via SPG Membrane Emulsification Technique"
    Langmuir 35 (2019) 4094–4100.
  10. A. Sakamoto, P. Qi, S. Ohba, S. Ohta, Y. Hara, T. Ogawa, M. Tomokiyo, A. Sasaki, H. Takizawa, M. Mochizuki, T. Ito and M. Honnami
    "Bone Regeneration by Calcium Phosphate-Loaded Carboxymethyl Cellulose Nonwoven Sheets in Canine Femoral Condyle Defects"
    J. Biomed. Mater. Res. Part B 107 (2019) 1516–1521.
  11. Y. Amano, P. Qi, Y. Nakagawa, K. Kirita, S. Ohta, and T. Ito
    "Prevention of Peritoneal Adhesions by Ferric Ion-crosslinked Hydrogels of Hyaluronic Acid Modified with Iminodiacetic Acids"
    ACS Biomater. Sci. Eng. 4 (2018) 3405–3412.
  12. M. Sakoda, M. Kaneko, S. Ohta, P. Qi, S. Ichimura, Y. Yatomi, and T. Ito
    "An Injectable Hemostat Composed of a Polyphosphate-Conjugated Hyaluronan Hydrogel"
    Biomacromol. 19 (2018) 3280-3290.
  13. S. Ohta, K. Hashimoto, X. Fu, M. Kamihira, Y. Sakai, and T. Ito
    "Development of Human-derived Hemoglobin-Albumin Microspheres as Oxygen Carriers Using Shirasu Porous Glass Membrane Emulsification"
    J. Biosci. Bioeng. 126 (2018) 533–539.
  14. P. Qi, S. Ohba, Y. Hara, M. Fuke, T. Ogawa, S. Ohta, and T. Ito
    "Fabrication of calcium phosphate-loaded carboxymethyl cellulose non-woven sheets for bone regeneration"
    Carbohydr. Polym. 189 (2018) 322-330.
  15. Y. Amano, Y. Nakagawa, S. Ohta, and T. Ito
    "Ion-responsive fluorescence resonance energy transfer between grafted polyacrylic acid arms of star block copolymers"
    Polymer 137 (2018) 169-172.
  16. T. Hozumi, T. Kageyama, S. Ohta, J. Fukuda, and T. Ito
    "An Injectable Hydrogel with Slow Degradability Composed of Gelatin and Hyaluronic Acid Crosslinked by Schiff’s Base Formation"
    Biomacromol. 19 (2018) 288-297.
  17. Y. Nakagawa, S. Ohta, M. Nakamura, and T. Ito
    " 3D inkjet printing of star block copolymer hydrogels cross-linked using various metallic ions"
    RSC Adv. 7 (2017) 55571-55576.
  18. S. Ohta, S. Hiramoto, Y. Amano, S. Emoto, H. Yamaguchi, H. Ishigami, J. Kitayama, and T. Ito
    "Intraperitoneal delivery of cisplatin via a hyaluronan-based nanogel/in situ crosslinkable hydrogel hybrid system for peritoneal dissemination of gastric cancer"
    Mol. Pharm. 14 (2017) 3105-3113.
  19. Y. Nakagawa, S. Ohta, A. Sugahara, M. Okubo, A. Yamada, and T. Ito
    "In vivo redox-responsive sol-gel/gel-sol transition of star block copolymer solution based on ionic cross-linking"
    Macromol. 50 (2017) 5539-5548.
  20. S. Wilhelm, A. J. Tavares, Q. Dai, S. Ohta, J. Audet, H. F. Dvorak, and W. C. W. Chan
    "Analysis of nanoparticle delivery to tumours"
    Nature Reviews Materials 1 (2016) 16014.
  21. S. Ohta, D. Glancy, and W. C. W. Chan
    "DNA-controlled dynamic colloidal nanoparticle systems for mediating cellular interaction"
    Science 351 (2016) 841-845.
  22. S. Ohta, S. Hiramoto, Y. Amano, M. Sato, Y. Suzuki, M. Shinohara, S. Emoto, H. Yamaguchi, H. Ishigami, Y. Sakai, J. Kitayama, and T. Ito
    "Production of cisplatin-incorporating hyaluronan nanogels via chelating ligand-metal coordination"
    Bioconjug. Chem. 27 (2016) 504-508.
  23. Y.-T. Lai, S. Ohta, K. Akamatsu, S. Nakao, Y. Sakai, and T. Ito
    "Size-dependent interaction of cells and hemoglobin-albumin based oxygen carriers prepared using the SPG membrane emulsification technique"
    Biotechnol. Prog. 31 (2015) 1676-1684.
  24. Y. Nakagawa, Y. Amano, S. Nakasako, S. Ohta, and T. Ito
    "Biocompatible star block copolymer hydrogel cross-linked with calcium ions"
    ACS Biomater. Sci. Eng. 1 (2015) 914-918.
  25. S. Ohta, K. Yamura, S. Inasawa and Y. Yamaguchi
    "Aggregates of silicon quantum dots as a drug carrier: selective intracellular drug release based on pH-responsive aggregation/dispersion"
    Chem. Commun. 51 (2015) 6422-6425.
  26. S. Ohta, S. Inasawa and Y. Yamaguchi
    "Alignment of vascular endothelial cells as a collective response to shear flow"
    J. Phys. D: Applied Physics 48 (2015) 245401.
  27. T. Hozumi, S. Ohta, and T. Ito
    "Analysis of the calcium alginate gelation process using a Kenics static mixer"
    Indust. Eng. Chem. Res. 54 (2015) 2099?2107.
  28. Y.-T. Lai, M. Sato, S. Ohta, K. Akamatsu, S. Nakao, Y. Sakai, and T. Ito
    "Preparation of uniform-sized hemoglobin?albumin microspheres as oxygen carriers by Shirasu porous glass membrane emulsification technique"
    Colloid. Surf. B 127 (2015) 1-7.
  29. A. T.H. Wu, T. Aoki, M. Sakota, S. Ohta, S. Ichimura, T. Ito, T. Ushida, and K. S. Furukawa
    "Enhancing osteogenic differentiation of MC3T3-E1 cells by immobilizing inorganic polyphosphate onto hyaluronic acid hydrogel"
    Biomacromol. 16 (2015) 166-173.
  30. S. Ohta, T. Nishiyama, M. Sakoda, K. Machioka, M. Fuke, S. Ichimura, F. Inagaki, A. Shimizu, K. Hasegawa, N. Kokudo, M. Kaneko, Y. Yatomi, amd Taichi Ito
    "Development of carboxymethyl cellulose non-woven sheets as a novel hemostatic sgent"
    J. Biosci. Bioeng. 119 (2015)
  31. Y. Nakagawa, S. Nakasako, S. Ohta, and T. Ito
    "A Biocompatible calcium salt of hyaluronic acid grafted with polyacrylic acid"
    Carbohydr. Polym. 117 (2015) 43-53.
  32. A. Takahashi, Y. Suzuki, T. Suhara, K. Omichi, A. Shimizu, K. Hasegawa, N. Kokudo, S. Ohta, and T. Ito
    "In situ cross-linkable hydrogel of hyaluronan produced via copper-free click chemistry"
    Biomacromol. 14 (2013) 3581-3588.
  33. Y.-T. Lai, S. Ohta, K. Akamatsu, S. Nakao, Y. Sakai, and T. Ito
    "Preparation of uniform-sized poly[methacryloxypropyl tris(trimethylsiloxy)silane] microspheres via Shirasu porous glass membrane emulsification technique"
    J. Chem. Eng. Jpn. 46 (2013) 777-784.
  34. S. Ohta, S. Inasawa, and Y. Yamaguchi
    "Real time observation and kinetic modeling of the cellular uptake and removal of silicon quantum dots"
    Biomaterials 33 (2012) 4639-4645.
  35. S. Ohta, P. Shen, S. Inasawa, and Y. Yamaguchi
    "Size- and surface chemistry-dependent intracellular localization of luminescent silicon quantum dot aggregates"
    J. Mater. Chem. 22 (2012) 10631-10638.
  36. S. Ohta, S. Inasawa, and Y. Yamaguchi
    "Size control of phase-separated liquid crystal droplets in a polymer matrix based on the phase diagram"
    J. Polym. Sci. Part B: Polym. Phys. 50 (2012) 863-869.
  37. P. Shen, S. Ohta, S. Inasawa, and Y. Yamaguchi
    "Selective labeling of the endoplasmic reticulum in live cells with silicon quantum dots"
    Chem. Commun. 47 (2011) 8409-8411.
  38. S. Ohta, S. Inasawa, O. Koike, M. Fujita, and Y. Yamaguchi
    "Formation of well-aligned thin films of rod-like nanoparticles via solvent evaporation: A simulation study"
    Appl. Phys. Express. 2 (2009) 065002-1-3.
  39. O. Koike, S. Ohta, M. Fujita, and Y. Yamaguchi
    "Simulation Model of concentrated colloidal rod-Like nanoparticles"
    Jpn. J. Appl. Phys. 47 (2008) 8124-8130.